Morning sickness is difficult to deal with and there are many safe options to help you manage morning sickness during pregnancy.

Diclegis (doxylamine and pyridoxine)

• FDA approved for treating nausea in pregnancy
• Drowsiness can occur with this medicine, so it’s important to avoid activities that require mental alertness, such as driving when taking it.

Doxylamine

• An antihistamine that’s available as a sleeping pill under the brand name Unisom Nighttime Sleep-Aid. (Don’t confuse Unisom Nighttime Sleep-Aid with Maximum Strength Unisom SleepGels – they’re two different things.)
• One caution: Doxylamine can make you sleepy, so don’t drive when taking it.
• Vitamin B6 and doxylamine have often been used in combination to treat morning sickness. In fact, the FDA has approved this combination for nausea and vomiting during pregnancy under the brand-name Diclegis

Metoclopramide: Brand name Reglan & Metozolv ODT

• A new study (?) has shown that this is safe for pregnant women
• This prescription is available in syrup, tablet-disintegrating, tablet, & solution form.

Emetrol

• A nonprescription nausea medication that is considered safe during pregnancy. It seems to reduce nausea by easing intestinal hyperactivity and appears to have no significant side effects. It can raise blood sugar in patients with diabetes, including gestational diabetes, so check with your doctor before taking if you are diabetic.

Zantac or Pepcid: Reflux medications

• Occasionally nausea and vomiting can be triggered by gastrointestinal distress. In these cases, reflux medications can be a safe and helpful solution.

Vitamin B6

• Vitamin B6 alone has been shown to reduce pregnancy-induced nausea.
• Vitamin B6 and doxylamine have often been used in combination to treat morning sickness. In fact, the FDA has approved this combination for nausea and vomiting during pregnancy under the brand-name Diclegis

Zofran

• Zofran is commonly administered to prevent nausea in chemotherapy and post-operative patients. It has also been safely prescribed for morning sickness during pregnancy. The most common side effect of Zofran is a headache, so if you are predisposed to headaches or migraines, you may want to consider another option.

Compazine (Prochlorperazine)

• Compazine is also known as Prochlorperazine oral (taken by mouth) is used to treat psychotic disorders such as schizophrenia. It is also used to treat anxiety, and to control severe nausea and vomiting.
• You should not use prochlorperazine if you have recently used sedatives, tranquilizers, or narcotic medications. Prochlorperazine is not recommended during the 3rd trimester of pregnancy. This drug should only be used during pregnancy under strict observation by your doctor.

Tigan

• Tigan is used to relieve nausea and vomiting. Tigan can cause drowsiness and should not be used while driving or operating heavy machinery until you are aware of how your body responds to the medication.

Phenergan (Note: Compazine and Phenergan should never be taken together.)

• Phenergan is used to treat allergy symptoms such as itching, runny nose, sneezing, itchy or watery eyes, hives, and itchy skin rashes.
  Phenergan also prevents motion sickness and treats nausea and vomiting or pain after surgery. It is also used as a sedative or sleep aid. It is sometimes prescribed to pregnant women who have severe morning sickness that does not respond to other treatments.